A new study from the University of Utah in the United States found that small cell lung cancer can be subdivided into different tumor subtypes. They also found that a targeted drug combination has a good therapeutic effect on one of the tumor subtypes. The relevant research results were published in the international academic journal Cancer Cell. These results indicate that different small cell lung cancers cannot be treated as the same disease.
Trudy G. of the University of Utah Professor Oliver led the study. She said: "Now the hospital will not perform genetic testing on patients with small cell lung cancer. They are treated with the same treatment after being diagnosed with small cell lung cancer. But our research It shows that small cell lung cancer is not exactly the same, which is very important for the choice of treatment."
For the first time, the researchers constructed a small cell lung cancer subpopulation mouse model called C-MYC, which is estimated to be about one-fifth of the small cell lung cancer patients. “C-MYC tumors look different from other tumors under the microscope, and this type of tumor is more aggressive, grows faster and spreads faster. Most importantly, their response to cancer treatments is also different."
Chemotherapy is the traditional treatment for small cell lung cancer. Although chemotherapy is effective in 80% of patients at the beginning, the tumor will soon become resistant to chemotherapy. Most chemotherapy drugs are not successful. But until now, these chemotherapeutic drugs have not been tested in the C-MYC in vivo model.
The researchers analyzed the characteristics of C-MYC tumors and later found that some drugs may work for this type of small cell lung cancer. A drug called Aurora kinase inhibitor combined with chemotherapy can improve the treatment of cancer mouse models. result.
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