According to research data released by the National Cancer Institute, more than 90% of cancer patients with treatment failure are associated with drug resistance. Therefore, studying the mechanism of tumor resistance, finding new anti-tumor targets and developing new anti-tumor drugs have always been the focus of global attention. MRP (MultidrugResistanceassociatedProtein, a multidrug resistance-associated protein) is a member of the ABC transporter family and is the first ABC transporter to be discovered and identified for drug resistance, and therefore has a particularly important role. MicroRNAs (miRNAs) are major discoveries in the field of RNA biology in recent years. There are more than 1000 miRNAs expressed in humans, and 60% of the genes in humans may be regulated by it. It is a small class of non-coding RNAs with an average length of only 22 nucleotides, and its regulation of target genes is involved. A series of biological processes such as individual development, cell differentiation and proliferation, and apoptosis play an important role in the generation and development of human diseases such as tumors and metabolic disorders, but their roles and mechanisms in tumor resistance are still not Very clear.
Using the latest techniques and methods in molecular biology, Gorman found that miR-145 can act on the binding site of the 3'UTR of ABCC1 through incomplete base pairing and down-regulate the expression of the target gene MRP1 at the post-transcriptional level. Important new mechanism. Further in vitro and in vivo studies have shown that miR-145 can down-regulate MRP1, reduce the efflux of intracellular doxorubicin, increase the accumulation of doxorubicin in cells, and enhance the sensitivity of breast cancer cells to doxorubicin. This provides new targets, new mechanisms and new treatments for anti-tumor resistance research.
The research work was published online on Oncotarget in July 2016. It is the first time that a new molecular mechanism for the dual regulation of non-coding miRNAs was discovered in the international journal BBA-GeneRegulatoryMechanisms in March this year. The evaluation center's research on non-coding miRNAs has been published in several articles. From the discovery of new mechanisms for the dual regulation of non-coding miRNAs, to the new functions of non-coding miRNAs against tumor resistance, non-coding miRNAs have been established. A series of research systems, such as discovery, screening, optimization, function and mechanism confirmation, have made a series of new developments and have been widely recognized in foreign countries.
The research was supported by the National Science and Technology Major Project of “Major New Drug Creation†and the special project of the Chinese Academy of Sciences.
Ready-to-eat Double Packed Sweet Corn
In this category is sweet corn from Jilin Province Agricultural Sister-in-law Food Co.
The physical characteristics of maize consist of grain colour, grain shape, seed coat lustre, grain length, grain width, 100 grain weight, grain diameter, uniformity of the seed and hardness. In most cases, the colour of the endosperm of mature maize kernels is yellow or white, while the seed coat and paste layer are colourless and transparent. Depending on the colour of the kernels, there are three types of maize: yellow, white and mixed. Depending on the kernel form, hardness and different uses, maize is divided into two types: common maize (hard, intermediate, horse-tooth, hard-horse, horse-hard) and special maize (high-lysine maize, high-oil maize, sweet maize, cracked maize, glutinous maize).
The sweet corn of Jilin Province Agricultural Sister-in-law Food Co., Ltd. belongs to the special corn category of yellow corn.
Also known as fruit corn. The leaves on the outside are light green (only the ears are in the pack, we have removed the leaves for you) and the kernels inside are white or yellow. Sweeter than regular sweet corn, but lower in starch and rich in vitamin E and fibre, which is anti-ageing and aids digestion. Perfect for eating raw, mixed with vegetables in salads; it can also be steamed, but don't cook it for too long, about 5 minutes.
If you have any questions, please contact us directly. If you have any questions, please email us directly.
Delectable Sweet Corn Cob,Microwave Sweet Corn Cob,Country Sweet Corn,Ready To Eat Sweet Corn
Jilin Province Argricultural Sister-in-law Food Co., Ltd. , https://www.nongsaocorns.com