Release date: 2014-06-30
Modification of hydrogels is a prerequisite for the application of hydrogels in many ways. The hydrogel has many excellent properties in drug release, substance separation, organ transplantation, tissue culture, enzyme immobilization and immunoassay, and has attractive application prospects in the biomedical field. Guo Zhenchao and others from the School of Biological Science and Medical Engineering of Southeast University made a detailed analysis. The research was published in the April 2014 issue of Hans's Frontier of Materials Chemistry.
Wound dressings and artificial organs. Highly water-absorbent gel, also known as super absorbent resin, absorbs 10 to 5000 times its own weight of water, salt water, ammonia, urine and blood. PVA hydrogel absorbs a large amount of exudate without sticking to the wound and is not susceptible to infection. It is also used in artificial joints, artificial muscles, artificial vitreous, artificial corneas, and irises.
Tissue cell culture. The modified PEG hydrogel covalently binds to vascular endothelial growth factor (VEGF) to increase the initial planting efficiency of seed cells on bioscaffold materials; the addition of transforming growth factor (TGF-β1) promotes extracellular matrix (ECM) produce. The short peptide arginine-glycine-aspartate (RGD) enhances adhesion between cells and cellular material. Isopropyl acrylamide (PNIPA) gel can successfully perform in vitro and in vivo transplantation studies on cartilage, skin, cornea and liver.
Molecular detection and separation. The gel is used for the separation of proteins, enzymes, antigens and antibodies because of the crosslink density or monomer structure of the gel designed according to the isolated substance, and the method is fast, sensitive and accurate compared with the conventional method.
Smart materials and biosensing. Intelligent hydrogels respond to subtle changes or stimuli in the environment. Shape memory materials of interest can be made with PVA hydrogels. Immunoglobulin G (IgG), bovine serum albumin (BSA), and fluorescein isothiocyanate (FITC), which are low in concentration, are detected by liquid crystal protein analysis.
Drug sustained release carrier and microcapsules. The liposome has a radius between 10 nm and 100 nm, and the drug is encapsulated in the hydrophobic domain between the inner aqueous phase and the bilayer structure in the structure, and the pathogen cell is identified by modifying a surface of the liposome with an identifying substance such as an antibody. Structure. The PVA hydrogel is used as a drug carrier, and is combined with a small molecule drug in a binding form, or the gel is made into a microcapsule, and the small molecule drug is embedded, so that the drug release time is greatly prolonged, and the drug is reduced. The amount used.
Source: Irvine Culture
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