I have independently cultivated the world's first genetic editing clone dog.
July 06, 2017 Source: Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];When a puppy is genetically edited and cloned into another "self", how will it be novel? Now, the Chinese are the first to make it! On the 5th, Beijing Sino Valley Biotechnology Co., Ltd. officially announced that the author’s identification of the Beagle “Dragon†and the world’s first genetically edited disease model dog “Apple†was more than 99.99%. The surrogate dog excludes the parent-child relationship, which proves that the "Dragon Dragon" is the cloned dog of "Apple". "Dragon" became the first somatic clone dog in China to be completely self-cultivated, and it is also the world's first genetically edited cloned dog.
"This marks that China has become the second country to independently master the canine somatic cell cloning technology after South Korea," said Lai Liangxue, a researcher at the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences.
After the birth of the first somatic cell clone "Dolly", humans cloned a variety of mammals such as mice, cattle, goats, pigs, etc., but cloned dogs have not been made. Dogs are widely regarded by the scientific community as one of the most difficult animals to clone. This is because there are many bottlenecks in canine somatic cell cloning technology, and technology in this field has always been monopolized by South Korea.
Lai Liangxue led the company's research team, using the latest gene editing technology CRISPR/Cas9, knocked out the APOE gene of dogs, elevated plasma cholesterol, induced atherosclerotic lesions, and successfully developed the world's first atherosclerotic disease model. Dog "Apple". Later, the researchers developed a cloned dog of "Apple" and improved the implantation efficiency and pregnancy rate of canine cloned embryos by optimizing the technology platform.
The popular interpretation of the above process is that people edit the dog gene, "customize" its function, and then copy it as a model to achieve "bulk" production. This is the first time in China and the world.
"China has successively developed genetically edited monkeys and genetically edited dogs. In the preparation of large animal disease models, China has been at the forefront of the world." Lai Liangxue introduced that after the breakthrough of cloned dog technology, people can "customize" functions according to their needs, such as A group of experimental dogs with the same genetic background and similar age are cultivated at one time to study the mechanism of disease occurrence and verify the efficacy of new drugs; knocking out or knocking in a certain gene of the dog makes the dog's sense of smell more sensitive and muscles more developed. Become a good police dog or search dog and other working dogs; you can also copy the same dog after the death of the dog, so that the owner's feelings can continue.
According to Mi Jidong, co-founder of Sino Valley, at present, the second surrogate dog has two cloned dogs of “Apple†and has been identified by DNA identity. They will also develop a variety of disease model dogs and functional gene editing dogs such as autism, and promote the commercialization of canine cloning technology. (Chen Lei)
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