[Inventory] Human genome sequencing project led by governments around the world

American scientists first proposed the Human Genome Project in 1985, officially launched in 1990, and scientists from the United States, Britain, France, Germany, Japan, and China participated in the $3 billion Human Genome Project. Later, on June 26, 2000, scientists from the six countries jointly announced that the drafting of the human genome sketch had been completed. After the large-scale and world-influencing gene sequencing project ended, there are different countries in the world competing to carry out their own genome sequencing projects. The author has roughly combed the countries with actions:

China

Recently, the National Health and Family Planning Commission released news that China is formulating a " precise medical " strategic plan, which will be included in the 13th Five-Year Major Science and Technology Project. In addition, Academician Zhan Qimin, a member of the National Precision Medical Strategy Expert Group, believes that precision medicine is the application of modern genetic technology, molecular imaging technology, and biological information technology, combined with the patient's living environment and clinical data, to achieve accurate disease classification and diagnosis, and to develop personalized treatment. The development of precision medicine for the program is a good opportunity for China. The competent authorities have considered incorporating precision medicine into a work focus of the 13th Five-Year Plan. Before 2030, China's precision medical care will invest 60 billion yuan, of which the central government will pay 20 billion yuan, and the enterprise and local finance will support 40 billion yuan.

Related to precision medicine is in November this year, the Shengjing Hospital affiliated to China Medical University and the Genetics Advisory Branch of the Chinese Genetic Society launched the "China Twin-Fetal Genome Project", gradually establishing a standard specification for non-invasive prenatal testing of twins, promoting non-invasive prenatal The application of detection technology in twin pregnancy.

This is related to the liberalization of the second-child policy and the development of assisted reproductive technology, which leads to more and more current reality of twin pregnancy. However, China currently lacks the exact method for prenatal diagnosis of twins, so it is necessary to have high-accuracy non-invasive Prenatal screening. The "China Twin Fetal Genome Project" will complete non-invasive prenatal testing of 10,000 twins in three years.

United Kingdom

On November 12, 2015, the British government's wholly-owned British Gene Company announced an agreement with China Mingma (Shanghai) Biotechnology Co., Ltd. to participate in the UK's “100,000 Genome Project” to provide genomic data analysis tools. Help researchers improve the quality of data analysis.

The UK's "100,000 Genome Project" was presented by British Prime Minister David Cameron in December 2012 and implemented by Genomics England, and is scheduled to be conducted outside of 2017 for 100,000 patients at the National Health Service. Sequencing. Launched in 2012, the government aims to sequence the complete genome of 100,000 patients in the UK National Health System (NHS) record.

The goal of the project is to develop personalized cancer and rare disease therapies based on genomics and clinical data, and to make NHS the “world's first mainstream health care system that will provide genomic medicine as part of routine care”. This project not only allows participants to benefit from clinical analysis, but their genomic data also contributes value to patients across society. For example, a doctor comparing a prostate cancer gene in a patient with data from a UK genetic database may reveal the specific genetic pattern behind the disease. The doctor may find other patients with the same genetic model and then learn which drugs and procedures are beneficial to the patient.

It is reported that the project will receive a combined investment of more than 300 million pounds, which is expected to make the UK a global leader in genetic research on cancer and rare diseases.

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