The first month has not yet come out, and the party's wine board is still continuing. The reminder about "eating antibiotics (especially cephalosporins) when you don't drink alcohol, drinking alcohol is equivalent to drinking poisons, which can easily cause sudden death" is sensational to the circle of friends. In fact, this is completely misunderstood. It is just that the cephalosporin and alcohol have been called “disulfiram reactionâ€.
Cephalosporin makes the amount of alcohol smaller, drunk faster
The disulfiram reaction sounds very professional and medical. In fact, it is simple to say, but it is caused by certain drugs that interfere with the metabolism of alcohol, resulting in "drinking down" and entering drunken state faster than usual. It does not produce "poison poisoning" results. For sensitive populations, as long as pathogenic drugs are used, the more you drink, the more obvious the symptoms are, and there is not much to do with taking medicine.
The vast majority of patients who have undergone disulfiram do not require special treatment. Due to the vasodilating effect of acetaldehyde, patients who experience a disulfiram reaction experience a transient decrease in blood pressure. For formerly healthy patients, taking a break from alcohol exposure and taking a short rest in the supine position can relieve the symptoms.
Do not drink after taking medicine? Drink it after three days
It seems that although the disulfiram reaction after taking cephalosporins and other drugs only affects the degree of intoxication and progress, it has a temporary impact on the body. For safety reasons, it is best to drink for 3 to 5 days after stopping.
Therefore, normal adults will not experience disulfiram after drinking 3 to 5 days after taking antibiotics. However, it should be mentioned that the elimination half-life of drugs for infants and older persons over 75 years is usually 2 to 3 times longer than that of normal adults. Such people, such as exposure to alcohol and pathogenic antibiotics, need to be vigilant.
Drinking drowning? Cardiovascular disease
Then, there are many cases of drunken deaths that have exploded in the news. Is this something else?
In fact, the sudden death after drinking is mostly occurring in patients with previous cardiovascular and cerebrovascular diseases. Drinking is just one of the factors that cause the increase of cardiovascular and cerebrovascular diseases. Analysis of several cases of sudden death due to suspected disulfiram in existing domestic and international literature. All patients have underlying disease (or autopsy demonstrated coronary artery occlusion) and cannot be rigorously proven to be due to the disulfiram reaction leading to death of the patient. .
How much can predict the amount of alcohol? Hospital to do a test
"Liquor" is related to people's own genes. Those who have the ALDH2*2 gene are more likely to have adverse reactions to drinking. The clinical pharmacology laboratory of the General Hospital of the Chinese People's Liberation Army has been able to detect the metabolism of each person's alcohol by means of drug metabolism genetics and speculate on each person's "drinker." If people with ALDH2*2 homozygotes, it is best to avoid drinking for life.
However, a person's alcohol intake (alcohol metabolism clearance rate) is not only related to the innate gene, but also affected by a variety of external factors, such as basic diseases, drinking mood, drinking speed, etc., can all lead to our “decrease in drinking capacityâ€.
Therefore, even if the genetic testing did not carry the "easy drunk" gene, do not drink too much, moderately healthy drinking.
Related Reading
Which drugs are prone to cause disulfiram reactions?
Yin Ming, deputy chief physician of the Emergency Department of the South Building of the People's Liberation Army General Hospital: A drug with a side chain of thiazolamide inhibits acetaldehyde dehydrogenase and can cause disulfiram reactions. Including cefoperazone in the cephalosporins, cefoperazone sulbactam, ceftriaxone, etc., among which the report of the disulfiram-like reaction caused by cefoperazone is the most sensitive. However, cephalosporins that do not contain thiazolidine groups, such as cefotaxime, ceftazidime, and macrolides (such as azithromycin), do not cause disulfiram-like reactions during alcohol use. In addition, drugs with imidazole groups and chloramphenicol, tolbutamide, glibenclamide, isoniazid, etc. can inhibit alcohol metabolism, drinking after drinking can occur disulfiram-like reaction.
In addition, some patients may experience mild disulfiram-like reactions after taking drugs, eating chocolate, drinking water, or even treating the skin with alcohol alone (alcoholic toilet water).
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