Based on its ultra-high resolution electrostatic field orbitrap mass spectrometry platform combined with its powerful software platform, Thermo Fisher offers a full-scale solution for metabolomics. The program covers not only the comprehensive detection of polar metabolites to non-polar metabolites, peak extraction and quantification, statistical analysis and visualization, comprehensive identification of metabolites, metabolic pathway analysis, but also integration. Analytical requirements at different levels of metabolomics from non-target biomarker discovery to target biomarker validation.
Metabolomics full process workflow
Excellent hardware solution
Thermo Scientific's Orbitrap technology is a new mass spectrometry technology for nearly 30 years. Its ultra-high resolution, excellent mass accuracy, excellent sensitivity, excellent stability and quantitative ability comparable to QQQ make it comprehensive. Meeting the challenges of metabolomics has become a powerful analytical platform for metabolomics research.
First, super high resolution
Eliminating interference from complex matrices, comprehensive detection of metabolomic metabolomics analysis of sample matrices is complex, and requires simultaneous detection of full components in a limited analysis time, while ultra-high resolution is complex for analyzing those matrices. Samples with high interference are especially important.
Provides the current research field of metabolomics. The metabolic flow group (Fluxomics) for the ultra-high-demand metabolic flow group of resolution realizes the effective tracking of the flow direction and regularity of metabolites in the metabolic network by marking the metabolites in the body. Hotspots and frontiers in today's metabolomics research. In the study of metabolic flow groups, ultra-high resolution is more important.
Second, high quality accuracy
Ensure that the high-quality accuracy of each point of the MS peak is different from that of a typical high-resolution mass spectrometer. The Orbitrap mass spectrometer platform is based on its unique principle and stability to ensure that each collection point in the chromatographic peak achieves a mass accuracy of less than 1ppm, ensuring Accurate calculation of the composition of metabolite elements.
Simultaneously providing MSMS with a mass accuracy of less than 1 ppm, the Orbitrap mass spectrometer platform provides MSMS with mass accuracy of less than 1 ppm, which is critical to ensure the fine identification of metabolite structures.
Third, the quantitative ability comparable to QQQ
A platform for seamless integration of non-target qualitative/target quantitative analysis The Orbitrap mass spectrometer platform offers a highly sensitive, 5 orders of magnitude dynamic range and a flexible quantitative scanning mode that is both qualitative and has excellent quantitation capabilities.
Fourth, excellent stability
Meeting the High Reproducibility of Metabolomics Analysis Orbitrap Mass Spectrometry Platform provides high reproducible mass spectrometry data for mass accuracy and response intensity required for metabolomics analysis due to its unique structure and design. Comparison of biological differences provides a reliable basis.
Five, effective positive and negative ion switching scan
High-throughput Orbitrap mass spectrometry platform for large sample analysis enables real-time positive and negative switching scanning. Simultaneous acquisition of positive and negative ion spectra in one injection without loss of sensitivity and mass accuracy can greatly improve metabolomics analysis Experimental flux.
Powerful software solution
Based on high-quality raw data collected by the Orbitrap mass spectrometer platform, Thermo Scientific provides a comprehensive and powerful software platform for data processing and bioinformatics mining of metabolomics.
First, SIEVE software - professional metabolomics data processing, information mining software
• A unique component extraction algorithm that takes into account all mass spectral ion responses attributed to a metabolite;
• Fine isotope matching algorithm to more accurately determine metabolite element composition;
• Metabolomics statistics modules such as principal component analysis and T-test;
• Associated with a variety of commonly used metabolomics databases such as KEGG to automatically search for differential components.
• Pathway Mapping.
Second, a powerful database library and structure analysis software
mzCloud - multi-level library and analysis of all unknown metabolite structures;
• SIEVE online links to common metabolomics databases such as HMDB and KEGG;
• Mass Frontier Software—Automatic Mass Spectrometry Structure Analysis Software, Fragmentation LibraryTM Fragmentation Library, covering more than 99% of published literature on fragmentation mechanisms, predicting fragment ions of compounds, including 150,000 unique The above chemical structure and more than 30,000 pieces of fragmentation.
Third, TraceFinder software - high-throughput library search and quantitative software
• Establish a spectral database for data management and search for compounds;
• High-throughput target metabolite screening and identification;
• High-throughput quantitative analysis and heat map of target metabolites;
• Automatic conversion of qualitative screening results and quantitative methods.
Based on the Orbitrap ultra-high resolution mass spectrometry platform, the metabolomics full-process solution can provide the most excellent platform for today's metabolomics research, and comprehensively meet metabolomics in the fields of disease biomarker search, food omics, and traditional Chinese medicine. The challenge of research.
What's red light therapy? Red light therapy before and after
Red light therapy (RLT) is a treatment that may aid in the healing of skin, muscle tissue, and other body components. It exposes you to red or near-infrared light at modest intensities. Infrared light is a sort of energy that your eyes cannot see but which your body perceives as heat. Red light is comparable to infrared light, however it is visible.
Low-level laser treatment (LLLT), low-power laser therapy (LPLT), and photobiomodulation are all terms for red light therapy (PBM).
What Is Red Light Therapy and How Does It Work?
Red light treatment involves exposing your skin to a red-light bulb, gadget, or laser. Mitochondria, also known as the "power generators" of your cells, absorb it and use it to produce additional energy. This, according to some scientists, helps cells repair themselves and grow healthier. This promotes skin and muscular tissue repair.
The skin is not injured or burned by red light treatment since it employs very low amounts of heat. It is not the same sort of light used in tanning salons, and it does not expose your skin to UV rays that are harmful to your skin.
What Is It Used For?
Red light treatment has been studied for a long time. However, there aren't many research on it, and no one knows if it's better than other sorts of healing treatments. The use of red light therapy may be beneficial in the following situations:
Dementia. People with dementia who received near-infrared light treatment on their heads and via their nostrils on a daily basis for 12 weeks had improved memory, slept better, and were less irritable.
Pain in the teeth. People with temporomandibular dysfunction syndrome (TMD) experienced decreased discomfort, clicking, and jaw soreness after receiving red light treatment, according to another small study.
Hair loss is a common occurrence. In one research, men and women with androgenetic alopecia (a hereditary condition that causes hair loss) gained thicker hair after using an at-home RLT device for 24 weeks. The outcomes were not the same for those who utilized a bogus RLT gadget in the trial.
Osteoarthritis. According to one research, red and infrared light treatment reduced osteoarthritis-related pain by more than half.
Tendinitis. RLT appears to reduce inflammation and discomfort in persons with Achilles tendonitis, according to a small trial of seven participants.
Wrinkles and other symptoms of aging and damage to the skin. RLT has been shown in studies to aid with wrinkles and skin smoothing. RLT can also assist with acne scars, burns, and sun damage indications.
What Are the Consequences?
Even though experts aren't clear how or why red light treatment works, it's usually thought to be safe. There are also no hard and fast guidelines on how much light to use. Too much light can harm skin tissue, while too little can make it less effective.
What Is Red Light Therapy and Where Can You Get It?
At most cases, it's done in a doctor's office. Some salons and dentistry clinics, however, do it as well. You may also purchase a red light treatment gadget on your own. Side effects and injuries are more likely to occur with salon and at-home treatments. If you're considering red light treatment, see your doctor first.
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Shenzhen Guangyang Zhongkang Technology Co., Ltd. , https://www.szlighttherapymachine.com