According to foreign media reports, the researchers have developed a new micro-sensor that can directly monitor and adjust the composition of kidney dialysate, which is an important step in customizing dialysis for individual patients. The sensor provides a method to monitor the salt concentration in the dialysate, which can continuously adjust the concentration of the dialysate. The ability to monitor and adjust the salt concentration in the dialysate can reduce the side effects that can be caused by using standard dialysates, such as arrhythmias and kidney disease.
Manoj Kumar Sharma, a researcher from Eindhoven University of Technology, has developed a microdialysis system with a centrally located microchannel through which dialysate flows. His light-induced electron transfer (PET) covering the sensor molecule of the microchannel wall, only in the presence of salt will fluoresce. The more salt in the dialysate, the stronger the fluorescence. To enhance this effect, Sharma introduces a microcolumn into the microchannel to cover the larger surface area of ​​the sensor molecule; then lasers the microchannel to activate the fluorescence of the sensor molecule; then use the glass fiber attached to the microsystem channel Dimensions capture fluorescence; then, light passes through the fiber to the spectrometer for analysis. The analysis process first filters out a laser different from the fluorescence wavelength; then, based on the measured fluorescence intensity, the sodium concentration is measured.
It is important to ensure that the sensor molecules are not disturbed by other salts so that the concentration of a particular type of salt (in this case sodium) can be accurately measured.
The microfluidic sensor system measures approximately 5 x 2 cm and is now capable of accurately measuring sodium concentration in real time. Sharma pointed out that this technology is likely to be used in dialysis machines. Because the technology is relatively inexpensive, stable and accurate. In addition, he expects the size of this sensor system to be further reduced to around 1*1 cm for easy integration into dialysis machines. At the same time, this technology may eventually become part of the portable artificial kidney, because this solution can greatly alleviate the pain of patients with kidney disease .
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