Rhesus monkey hyperthyroidism model validates vaccines and progresses in the development of human hyperthyroidism vaccine
June 27, 2019 Source: Xinhuanet
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Xinhua News Agency, Xi'an, June 26 (Reporter Yan Juan) The world's first rhesus monkey hyperthyroidism model was delivered to the First Affiliated Hospital of Xi'an Jiaotong University from Kunming Animal Institute of Chinese Academy of Sciences on the 25th. Shi Bingyin, the president of the hospital, announced that his team has successfully prepared the rhesus monkey hyperthyroidism model for the first time in the world after years of scientific research, and through comparative experimental methods, it can be proved that the induction of immune tolerance in the neonatal period can effectively prevent the onset of primate hyperthyroidism. . The research results have laid a solid scientific research foundation for the development of human hyperthyroidism vaccine and the prevention of hyperthyroidism.
Shi Bingyin introduced that the team led by the team successfully prepared the model of hyperthyroidism in mice in 2011, which successfully induced the immune tolerance to hyperthyroidism for the first time in the world, proving that hyperthyroidism can be prevented by vaccination and published in the international professional journal Endocrinology. research report. Due to the close homology between rhesus monkeys and humans, the team induced the rhesus monkey Graves' hyperthyroidism in 2013. Hyperthyroid monkeys showed most of the characteristics of human hyperthyroidism. This study proved that non-human primates The feasibility of preparing Graves formazan in animals, the research results were published in the international journal Journal of Endocrinology.
Subsequently, Dr. Wu Liping and Dr. Guan Xiaoyan, the backbone of the team, conducted more than four years of research work at the Kunming Institute of Zoology, Yunnan Academy of Sciences, and established a complete experimental method for constructing the model of the rhesus monkey hyperthyroidism. The team proved by comparison of experimental methods that the use of vaccines can prevent the onset of primate hyperthyroidism, and the prevention rate of sputum injection to hyperthyroidism is over 90%. According to the scientific research report, no new immune tolerance therapy for Graves disease was established at home and abroad, and the rhesus monkey Graves hyperthyroidism model was prepared, and the same literature report on the tolerance of Graves hyperthyroidism was successfully induced.
According to reports, hyperthyroidism, known as hyperthyroidism, is an autoimmune disease. The incidence of hyperthyroidism is higher, the prevalence rate of the population is 1%, and the prevalence rate of the female population is as high as 1.9%. The anti-thyroid drugs, radioactive iodine and surgical treatments that have been used for nearly a hundred years are not ideal. Exploring the new prevention and treatment methods of hyperthyroidism, especially the development of human hyperthyroidism vaccine, has always been a major issue in the field of endocrinology.
Shi Bingyin said that the successful preparation of the rhesus monkey hyperthyroidism model and the successful verification of the hyperthyroidism vaccine indicate that China is at the international leading level in this research field, laying a solid scientific research foundation for the research and development of human hyperthyroidism vaccine and the prevention of hyperthyroidism.
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