Release date: 2016-07-04
Image source: medicalxpress.com
-- Recently, a study published in Cell , researchers from the Dana-Farber Cancer Institute and the University of California in the United States identified a natural molecular pathway that could help fat cells. Burning calories instead of storing calories, research or providing new ideas and hopes for developing treatments and inhibiting obesity, diabetes and other obesity-related metabolic syndromes such as cancer.
In the article, the researchers revealed the mechanism of burning energy of brown and light brown fat cells in the mouse body. They found that an enzyme called PM20D1 secreted by fat cells can induce the production of N-acyl amino acids. These N- Acylamino acids can separate fat burning from other metabolic processes, thereby promoting weight loss. Such decomplexers are known synthetic chemicals, and N-acyl amino acids are also the first known to researchers. Decomposing active natural small molecular substances.
When N-acyl amino acids were injected into the body of obese mice fed a high-fat diet, the researchers found that after 8 days of treatment, the body weight of the mice was significantly reduced, and the weight loss occurred entirely in adipose tissue. . Researcher Spiegelman said the data suggest that PM20D1 or N-acyl amino acids themselves may be used to help develop new therapies for the treatment of obesity and obesity-related syndromes.
The color of brown fat originated from a large number of mitochondria. Previously, researchers found brown fat in the animal body, and also a small amount of brown fat in the human body. Mitochondria are the site of cellular respiration, which can convert glucose into ATP molecules. And ATP can transport chemical energy to drive cells to function. Brown fat can consume glucose under the precursor of not making ATP. This is called "uncoupled respiration." Instead of producing ATP, brown fat cells use their energy to burn the calories stored in fat, thereby releasing. A lot of heat.
Initially, brown fat cells could evolve into cells that protect newborns from hypothermia, but the researchers found that brown fat cells may also be used to develop new therapies for obesity, many of which are currently in large numbers in laboratories and companies. Research to increase the supply of brown fat in the human body.
In previous studies, the researchers thought that a mitochondrial protein called UCP1 (uncoupling protein 1) was the only source of heat produced by brown fat cells, and UCP1 was only found in brown and light brown fat cells. Now, researchers have discovered another alternative pathway that does not rely on UCP1 protein, which is the activation of energy in newborn cells and liver by N-acyl amino acids. The researchers say that obese mice given N-acyl amino acids lose weight. Very obvious, of course, this needs to be evaluated and determined in later studies.
Source: Bio Valley
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