Chinese medicine to the era of quantification: Chinese scientists unlock the mystery of the prescription

"These results not only lead the Chinese medicine to the quantification era, but also enrich the content of the TCM individualized medical model," said Zhou Hongyu, an academician of the Chinese Academy of Engineering.

“The medicinal taste is tight and the weight is even more important.” The drug dose is the key to achieving good clinical results. For a long time, due to the lack of in-depth systematic research on the theory of Chinese medicine prescriptions, it has always stayed in the traditional, fuzzy description and generalization stage, which has restricted the development of traditional Chinese medicine.

The latter is called "the ancestor of the sacred book", and the prescription of "Treatise on Febrile Diseases" is rare because of the lack of medicine, and the medicine is dedicated to the macro. It is known as the "prescription" and is widely recognized and used by the world Chinese medicine community. However, due to the age, the weights and measures have been mutated, so that the source dose of Zhongjing Jingfang has become the mystery of the ages. People often combine the Han Dynasty's prescriptions into three grams, which is the common sense of the current prescription. Clinically, the amount of single-flavored drugs has become smaller, the prescriptions have become larger and larger, and the taste of medicines has increased. The average number of single-agent medicinal tastes in the Treatise on Febrile Diseases was 4.81, while the average single-dose medicinal taste in modern Chinese medicine decoction prescriptions was about 3 times that of the prescription, reaching 14.64 flavors.

Vice president of China Academy of Traditional Guang An Men Hospital with Kobayashi as chief scientist, by the Institute of Chinese Academy of Traditional Chinese Medicine, Beijing University of Chinese Medicine, traditional Chinese medicine, Jiangxi University, Fuzhou University and other units of the experts of the research team for the first time a comprehensive research by the parties 50 The history of the clinical use of traditional Chinese medicine in the past 2000 years has profoundly revealed the sudden decline in the amount of prescription medicine in the late Tang and Song Dynasties, and the reason for the current consumption.

The scientists used pharmacological, toxicological, metabolomics, and other methods to treat diabetes, such as Gegen Qilian Decoction, Dachengqi Decoction for the treatment of acute incomplete intestinal obstruction, and Ma Xing Ganshi Decoction for treating children with bronchopneumonia. Meta-genomics, network pharmacology and other multi-disciplinary research, initially established a methodology for the study of dose-effect relationship of prescriptions, and proposed and confirmed the clinical dosage strategy such as "distribution by disease".

“Our research broke through the technical bottleneck of the confusion compound dose study, which confirmed the existence of a wide range of doses for Chinese medicine, and provided evidence-based medical evidence for the clinical expansion of the critically ill patients. Of course, when treating chronic diseases and treating diseases The dosage should be reduced as appropriate." Tong Xiaolin said.

"Study on the dose-effect relationship of prescription drugs is very difficult, but the prospects are broad, and it has just begun." Li Zhenji, executive vice chairman and secretary general of the World Federation of Chinese Medicine Societies, said.