Identification of Chinese medicine
ã€Characteristics identification】 Irregular oblong, gyro or irregular round, large and small, 3~15cm long, 2~9cm in diameter. Surface brown or light brown, deep and dense vertical and horizontal wrinkles, solid quality, cross-sectional surface yellow-white, powdery, very narrow skin, forming a layer of ring is faintly visible, the outer edge of the wood can see a few catheter bundles, radial. Very bitter taste.
[Physical-chemical identification] Take palmatine hydrochloride and jatrorrhizine hydrochloride reference substance, and add methanol to make a solution containing 0.5 mg per 1 ml as the reference solution. According to the thin layer chromatography (Appendix VI B) test, absorb 4μl of each of the above two reference solutions and the test solution under [Content Determination] and place them on the same silica gel G thin plate, using benzene-acetic acid B The ester-methanol-isopropanol-concentrated ammonia test solution (12:6:3:3:1) is used as a developing agent, developing agent, and is placed in an ammonia-saturated vapor-expanded developing cylinder, unfolded, taken out, air-dried and set in ultraviolet light. Lights (365nm) view. In the chromatogram of the test sample, fluorescent spots of the same color appear on the positions corresponding to the chromatogram of the reference substance.
[Content determination] Take this product powder 1g [Also take this product powder to determine the moisture (Appendix IX H first method)], accurately weighed, add methanol 40ml, heat reflux for 1 hour, filtered, with methanol 10ml washing dregs The combined washings and filtrates were evaporated and the residue was dissolved in an appropriate amount of methanol and transferred to a 5 ml volumetric flask. Methanol was added to the mark and shaken as a test solution. Another standard amount of palmatine hydrochloride reference substance, accurately weighed, add methanol to make a solution containing 0.2mg per 1ml as a reference solution. According to thin layer chromatography (Appendix VI B) test, 6 μl of the test solution and 2 μl of the control solution and 4 μl of the control solution were precisely pipetted and crossed at the same point on the same silica gel G plate, and the ammonia vapor and the developer were pre-saturated at the same time. Minutes of double-slot deployment in the tank, remove and dry. According to thin-layer chromatography (Appendix VI B thin-layer scanning method) for fluorescence scanning, excitation wavelength λ = 366nm, measured for the absorbance of the test sample and the reference absorbance integrated value, calculated, that is, too.
This product is calculated according to the dry product, containing palmatine hydrochloride (C21H22NO4.HCl) shall not be less than 0.030%.
Pharmaceutical intermediates refer to high-level intermediate products used for the synthesis of chemical drugs, and are "semi-finished products" in the process of chemical drug synthesis. The pharmaceutical intermediates industry is an important link in the pharmaceutical industry chain. Since pharmaceutical intermediates are mainly used in the production of pharmaceutical raw materials, the pharmaceutical intermediates industry is directly related to the pharmaceutical industry. Xi'an Helisheng Biotechnology Co., Ltd. is located in Weiyang District, Xi'an City, Shaanxi Province, China. It is a professional researcher and one of the leading manufacturers in the field of pharmaceutical intermediates. As a professional manufacturer and exporter of pharmaceutical intermediate products in China, we have professional Our products are of reliable quality and reasonable price, mainly Tert-Butyl Carbamate, Ethyl Bromoacetate, 1-Phenyl-1 3-Butanedione, Propionic Anhydride, Tert-Butyl Bromoacetate. 2-Bromotoluene, etc.
Pharmaceutical Intermediate
Xi'an Hollysince Biotech Co., Ltd. , https://www.hollysince.com