New progress in the introduction of cell-targeted drugs in China
March 22, 2017 Source: Guangming Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Create new technologies for traditional targeted drug introduction technologies through scientific methods of “surgery†for cells. Recently, the micro-technical team of Jingzheng College of Tianjin University has made pioneering achievements in this field.
Recently, the micro-technical team of the Fine Arts Institute of Tianjin University has made important breakthroughs in the direction of cell-targeted drug introduction. For the first time in the world, the application of micro-electromechanical system (MEMS) thin-film resonators to stimulate 'extra high-frequency (gigahertz)' targets Introducing new technologies to cell drugs. By "surgery" for cells, they achieve precise introduction of a variety of molecules to cells, providing a new method for traditional targeted drug introduction technology, expanding the application of MEMS technology in life sciences. Relevant research results were published online recently in the internationally authoritative academic journal "Small" in the field of micro-nano technology.
The accurate and efficient introduction of exogenous molecules such as target drug molecules, therapeutic genes and proteins into the interior of cells is an important technology in modern precision medicine and cell molecular biology research. Traditional cell introduction relies on chemical drugs or electrical stimulation, such as the well-known "chemotherapy", which not only fails to introduce selective drugs, but also causes "cell immune response", destroying healthy cells and causing large side effects. The micro-nano device has the advantages of small volume and low power consumption, and can be implanted into the body to realize selective cell drug introduction. The use of micro-nano technology to realize single-cell drug introduction has become a hot spot in modern molecular biology research.
Microelectromechanical systems (MEMS) are MEMS systems consisting of movable components ranging in size from 0.5 to 500 microns. Under the joint efforts of team members such as Professor Pang Wei, Duan Xuexin and Associate Professor Wang Yanyan, the micro-technical team of Tianjin University has carried out a large number of research on micro-electromechanical resonators, sensors and actuators, and extended to life sciences and other fields, and obtained a number of independent knowledge. High-level scientific research results of property rights.
It is reported that the new technology is that the research team generates “extra high-frequency ultrasound†through the excitation of the resonator, and uses the vibration of “extra high-frequency ultrasound†to form small holes on the cell membrane efficiently and stably, and induce foreign substances such as targeted drugs or gene molecules to enter. cell. The ultra-high ultrasonic wave pressure on the cell membrane is about 60 times that of the general ultrasonic wave, and the cell membrane can be more uniformly stressed, so that the foreign matter can be accurately introduced into the cell and the nucleus, and the cell itself has no toxic and side effects.
The research team used mathematical and physical models to theoretically simulate the effects of high-frequency bulk acoustic waves on cells in liquids, revealing the physical mechanisms that lead to changes in cell membrane structure, and in the laboratory for different concentrations, different sizes, and different categories. The introduction of exogenous substances into the cell introduction experiment confirmed that the system has high efficiency, low power consumption, diversification, controllable introduction position, and multi-target, directed, single-cell drug introduction, and traditional drug introduction technology is not available. The advantages of comparison.
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The micro-technical team of Jingzheng College of Tianjin University proposed for the first time in the world that "the application of micro-electromechanical systems (MEMS) thin-film resonators to stimulate 'extra high-frequency (gigahertz)' for targeted cell drug introduction" is a new technology for China's cell targets. Indicate a new direction for drug introduction.
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