Release date: 2015-06-10
June 8, 2015 - Diabetes giant Novo Nordisk recently announced the launch of the diabetes cocktail Xultophy (IDegLira) in the UK, which is the third after the company successfully launched Xultophy in Switzerland and Germany earlier this year. EU countries. Xultophy is the world's first long-acting combination of insulin and GLP-1 receptor agonist, which combines hypoglycemic and weight loss benefits. It is a great boon for the majority of type 2 diabetes groups! The industry believes that Xultophy will become another heavyweight product of Novo Nordisk, with annual sales peaking over $1 billion.
Xultophy is a once-a-day injection of long-acting basal insulin Tresiba (insulin degludec) and glucagon-like peptide 1 (GLP-1) receptor agonist Victoza (liraglutide, liraglutide) Composition, which stimulates the secretion of natural insulin. Victoza (liraglutide, 1.8mg) is Novo Nordisk's annual sales of $2 billion and is a leader in the GLP-1 market. In clinical trials, liraglutide not only significantly improves glycemic control, but also effectively loses weight and improves obesity-related complications. Based on this discovery, Novo Nordisk developed liraglutide into a slimming injection Saxenda (liraglutide, 3 mg), and liraglutide became the first GLP developed in the world for weight management. -1 receptor agonist, the weight loss needle has been approved for marketing in the United States, the European Union and Canada. The industry believes that Saxenda's annual sales peak will reach $1.5 billion.
In the European Union, Xultophy was approved for the treatment of adult patients with type 2 diabetes in September 2014. The indications were oral hypoglycemic agents or group 2 diabetes with a combination of basal insulin but poor glycemic control. Clinical data show that Xultophy significantly reduced glycated hemoglobin (HbA1c) levels by 1.9% for patients with type 2 diabetes who had poor control of basal insulin therapy, with an average weight loss of 2.7 kg, and the probability of hypoglycemia was comparable to Tresiba.
At present, Xultophy has a bright future in the European market. From the sales performance after landing in Germany and Switzerland at the beginning of the year, the drug has been fully recognized by the market. However, compared to the EU's scenery, the prospects of Xultophy in the US market remain unclear. It is important to know that the FDA has previously refused to approve Tresiba and another compound product Ryzodeg (composed of Tresiba and insulin aspart Novolog) for cardiovascular risk. However, it is gratifying that the FDA decided to re-examine the two products in May this year and will make a review decision in October this year, which is undoubtedly a great news for Novo Nordisk.
In addition, according to FDA requirements, any compound product must consist of two or more approved drugs, Tresiba has been included in the US review, and Xultophy's regulatory application is just around the corner. If Xultophy is finally approved by the FDA, the future will be limitless.
Source: Bio Valley
Freeze-drying powder process includes: fresh fruit selection - cleaning - cutting - blanching - cooling - drying - grinding beating - gel grinding - sterilization - pre-freezing - vacuum freeze-drying - ultra-fine grinding - weighing packaging - testing - finished product.
Firstly, fresh and mature fruits with good quality were selected in the pre-treatment area of the food lyophilizer, and the leaves were removed to remove impurities. Then, preliminary cleaning and simultaneous sterilization of fruit surface were carried out. After sterilization, the fruits were cleaned and drained again. After the drain, the fruit is sliced and treated by blanching process. After the color preservation, the fruit is treated by pulping, and then pasteurized. The pretreatment process is finished before lyophilization.
The processing core of freeze-drying powder is the equipment area of food freeze-drying machine. After pre-treatment, the fruit enters the equipment of food freeze-drying machine and crystallizes into a solid state at low temperature, and then sublimates and dries in a vacuum environment to obtain freeze-drying products with little water content. Freeze-dried products out of the warehouse into the food freeze-dried post-processing area, ultrafine grinding, and then according to the need to do weighing packaging, after testing the finished products packed into storage.
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