PNAS: Zinc helps treat urinary tract infections
March 11, 2019 Source: Bio Valley
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UTI is one of the most common bacterial infections in the world, with approximately 150 million cases each year and can cause serious illnesses such as kidney infections and sepsis.
A team of researchers from the University of Queensland, led by Prof. Matt Sweet, Professor Mark Schembri and Professor Ronan Kapetanovic, studied how our immune system uses zinc to fight urinary tract infections in E. coli (UPEC), the leading cause of urinary tract infections.
Dr. Kapetanovic from the Institute of Molecular Biosciences (IMB) at the University of Queensland said researchers have known that zinc is toxic to bacteria. "We have confirmed through direct visualization that our immune system cells are called macrophages and can be used to remove bacterial infections," Dr. Kapetanovic said.
They also found that UPEC adopts a two-pronged strategy to maintain the body's immune response. "We found that UPEC can escape the zinc toxicity of macrophages compared to non-pathogenic bacteria, but these bacteria also show enhanced resistance to zinc toxicity.
"These findings provide us with clues to how our immune system fights infection, and potential ways to develop treatments, such as preventing UPEC from escaping from zinc, making it more sensitive to this metal.
“Therapeutic strategies that do not use antibiotics have the advantage that bacteria do not develop resistance; if we can reprogram our immune cells to make them stronger, or change their way of reacting to bacteria, we can better fight against super bacteria. ""
Dr. Minh Duy Phan of the University of Queensland's School of Chemistry and Molecular Biosciences said the study also identified a full set of UPEC genes that provide zinc toxicity protection. “These knowledge provides another potential way to develop antimicrobials for the treatment of UTI,â€
Information source: Zinc could help as non-antibiotic treatment for UTIs
Original source: Claudia J. Stocks, Minh-Duy Phan, Maud ES Achard, Nguyen Thi Khanh Nhu, Nicholas D. Condon, Jayde A. Gawthorne, Alvin W. Lo, Kate M. Peters, Alastair G. McEwan, Ronan Kapetanovic, Mark A. Schembri, Matthew J. Sweet. Uropathogenic Escherichia coli employs both evasion and resistance to subvert innate immune-mediated zinc toxicity for dissemination. Proceedings of the National Academy of Sciences, 2019; 201820870 DOI: 10.1073/pnas.1820870116
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