Professor of Nangong University: New compounds make cancer cells "sleep"
August 15, 2018 Source: Nanjing Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The scary thing about cancer is that cancer cells replicate very quickly and “kill†healthy cells by squeezing space. A study by Jonathan B. Beall, a professor at the School of Pharmacy at Nanjing University of Technology, can make cancer cells "sleep" and achieve cancer control. Recently, the result was published in the international top journal Nature.
The Jonathan team explained that KAT6A and KAT6B and their associated proteins are important drivers of certain cancers. In the blood cancer animal model of lymphoma, the team found that KAT6A gene loss increased the life expectancy of animal models by a factor of four. Therefore, if a molecule of suitable size and shape can be found, the process of cancer development can be competitively inhibited or blocked. After screening nearly 250,000 different small molecule compounds, they finally discovered a compound with acetylsulfonyl hydrazide as the core. The compound can prevent the cancer cells from dividing and proliferating in the animal body, control the cell cycle process of the cancer cells, promote the senescence, and finally cause the cancer cells to enter a permanent sleep state without causing irreversible damage to the normal DNA of the human body. The researchers said the compound would become a new anti-cancer weapon.
Jonathan B. Bell was a Principal Investigator of the Australian National Health and Medical Research Council. He is a professor of the Department of Medicinal Chemistry at Monash University in Australia. He came to South China University in March last year.
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