Release date: 2015-03-13
The study was based on a medical trial involving approximately 40,000 women conducted by the international Cochrane team. Although HRT drugs can alleviate menopausal symptoms and prevent heart disease, other potential hazards cannot be ignored. Experts have shown that if women are faced with a choice, they should discuss it with their doctors.
Cochrane researchers say their research is not the final conclusion to identify the benefits and risks of hormone replacement therapy. Experts point out that many women now regard hormone replacement therapy as a patch or gel rather than a drug, so it is important to fully understand the pros and cons of hormone replacement therapy and to discuss it with doctors.
Definition of hormone replacement therapy
So what is hormone therapy?
Hormone replacement therapy is a medical measure. When the body is deficient in hormones, and health problems occur or will occur, it is necessary to give drugs with sex hormone activity to the outer edge to correct the health problems related to sexual hormone deficiency. Women before and after menopause use "hormone supplementation therapy", which can not only relieve the occurrence of estrogen deficiency due to ovarian function decline, such as hot flashes, sweating, dizziness, insomnia, nameless irritability, vaginal dryness, loss of libido, etc., including autonomic nervous disorders, including A series of symptoms including mental disorders, but also prevent diseases such as cardiovascular disease, osteoporosis and senile dementia that may be transmitted due to long-term lack of sex hormones.
The pros and cons of HRT therapy
Research and negative news about hormone replacement therapy have been on the rise for many years. A large number of reports suggest it is associated with breast cancer, ovarian cancer and thrombosis. Although the risks do exist, most experts believe that hormone replacement therapy can help many women control annoying menopausal symptoms such as hot flashes.
One million British women are using various forms of hormone replacement therapy, pills, patches, or gels. The Cochrane team's comments are only for women taking HRT oral medication.
Studies have found that hormone replacement therapy has the following effects:
1. Reduce the risk of heart disease in women
2, increase the risk of blood clots, such as deep vein thrombosis
3, may increase the risk of stroke
However, this finding has not been subdivided - the effect will vary depending on the age of the woman, the period of menopause, and the duration of taking the HRT drug.
For example, the protection of the heart mentioned above can only be seen in the youngest female test group - women who are under 60 years of age or who have begun to receive HRT after entering menopause.
In absolute terms, the risk is small
According to the researchers' calculations, compared with 1,000 women who did not receive HRT, 1,000 women under the age of 60 who continued to receive hormone therapy for seven years may have five cases of blood clots and more than four strokes. At the same time, six deaths and eight heart disease cases were reduced.
Lead researcher Dr. Henry Boardman said the findings are subject to careful consideration. “This is a complex health problem. The same treatment benefits some women and also hurts some women.â€
The risk of stroke and thrombosis has been listed in the product information for women and prescribers. Experts recommend that women undergoing HRT undergo regular health checks and re-evaluate at least once a year if there is a need to continue treatment.
Professor Gynecology, a spokesperson for the Royal College of Obstetricians and Gynecologists, Janice Rymer, a member of the British Menopause Society, said that women do not have to be afraid to seek help in treating menopausal symptoms.
"If you are seriously overweight and have a family history of coagulation, then you may not be able to receive treatment. But we know that for most people, the risk is small and the absolute number is very small."
Prohibition and caution of hormone replacement therapy
Hormone replacement therapy should be banned in the following situations
(1) Unexplained vaginal bleeding.
(2) Tumors, with or suspected of breast cancer, endometrial cancer; have had "hormone-affected" tumors, such as patients with endometrial cancer.
(3) Unexplained uterine bleeding.
(4) Those with liver disease or liver dysfunction.
(5) Edema caused by heart, liver and kidney diseases, who had thrombophlebitis, connective tissue disease, otosclerosis, hematoporphyria, meningioma.
Hormone replacement therapy should be used with caution in the following situations:
(1) uterine fibroids, endometriosis, menstruation is still normal.
(2) Severe hypertension and diabetes.
(3) History of vascular embolism and tendency to thrombosis.
(4) Gallbladder disease, migraine, epilepsy, asthma, pituitary prolactinoma, etc.
(5) Family history of breast cancer.
Source: Bio-Exploration
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