The first analysis of how proteins in human cells are localized in cells was published online in Science on May 11. This study revealed that most of the human proteins were found to exist in more than one cell in a given cell. The location of the location.
Cell Atlas Project
Based on the Swedish Cell Atlas program, the researchers examined the spatial distribution of the human proteome that corresponds to most of the protein-coding genes, and described in detail the distribution of proteins in multiple organelles and subcellular structures.
Subcellular region involved in the study
The Cell Atlas program is the result of more than 10 years of research on the human protein Atlas program, which was launched in December 2016. This article in Science explains the analysis of thousands of images produced as international collaborations, including China, Korea, India, Denmark, and Germany.
Mathias Uhlen, the director of the Human Protein Atlas program, KTH professor, said: "Only by studying the body's smallest functional unit - the study of cellular molecular components, can we achieve a full understanding of the purpose of human biology research. Cell Atlas provides researchers with New knowledge is conducive to promoting the functional exploration of the role of individual proteins in human biology and disease."
Research purpose of subcellular localization
Within the cell, the organelle creates a partition that forms a closed environment to meet the chemical reactions of specific functions within the cell. Since these functions are closely related to a specific series of proteins, understanding the subcellular location of the human proteome is key to understanding the function and underlying mechanisms of human cells.
The study was led by Emma Lundberg, associate professor of high-throughput microscope equipment at the KTH Royal Institute of Technology in Stockholm, Sweden. The team produced more than 300,000 images to systematically address the spatial distribution of human proteins in cultured cells, localizing them to cell spacers and substructures at the resolution of single cells.
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