New nitric oxide targeted delivery system for precise treatment of vascular disease
January 15, 2019 Source: Science and Technology Daily Author: Sun Yusong Wu Junhui
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The reporter learned from Nankai University that Professor Zhao Qiang from the School of Life Sciences of the University and Associate Professor Shen Jie and Associate Professor Cheng Jiansong of the School of Pharmacy have spent four years researching and developing a new type of nitric oxide (NO) target using the principle of chemical biology "convex and concave complementation". To the delivery system, the system acts as a precise "switch" to deliver precise delivery of nitric oxide to the lesion during cardiovascular disease, effectively avoiding the release of nitric oxide from endogenous enzymes and the resulting side effect. A few days ago, the research results were published online in Nature·Chemical Biology.
According to reports, nitric oxide is an important gas signal molecule in the cardiovascular system, plays an important role in maintaining the normal physiological functions of blood vessels, and precisely regulates vascular homeostasis. The development of a precise nitric oxide delivery system to achieve targeted transmission is a bottleneck restricting the clinical application of nitric oxide biomaterials, and is also a hotspot in the field of cardiovascular and cerebrovascular diseases.
"Non-specific release means that in addition to the part of the lesion, there is a certain release in other tissues and organs of the body, so it has toxic side effects on the human body. And our new strategy is similar to the establishment of a drug 'processing plant' in the disease site. Through the intravenous delivery of prodrugs, through the blood circulation to reach the lesions, processing to produce nitric oxide, for disease treatment, to achieve precise targeting." Zhao Qiang said.
The researchers applied this "concave-concave complementary" nitric oxide delivery system to disease models such as rat lower limb ischemia and mouse acute kidney ischemia (AKI). The experimental results show that accurate nitric oxide transmission can promote angiogenesis more effectively, restore blood perfusion of lower limbs in rats, promote renal tissue repair in AKI mice, and effectively improve kidney function. Researchers have further validated the effectiveness of this novel nitric oxide delivery system in a mouse model of endothelial nitric oxide synthase knockout. "These findings suggest that the new nitric oxide delivery system and its biomaterials will provide new therapeutic strategies for vascular injury diseases in chronic diseases such as diabetes and atherosclerosis," said Zhao Qiang.
Functional oligosaccharides refer to oligosaccharides that are difficult or impossible to be digested and absorbed by the human body and have special physiological effects on the human body. Its sweetness is generally only 30-50% of that of sucrose, and it has physiological functions such as low-calorie, anti-caries, prevention and treatment of diabetes, and improvement of intestinal colony structure. Due to the special physiological functions of functional oligosaccharides, it becomes a nutrient and health care product. A new generation of food-effect raw materials that integrate diet and therapy. It is a new functional sugar source that replaces sucrose and has a wide range of uses and application prospects. Common functional oligosaccharides include: xylo-oligosaccharides, fructooligosaccharides, galacto-oligosaccharides, isomaltose, raffinose and so on.
XOS, GOS, FOS, IMO, Raffinose, oligosaccharide
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