Treatment of urinary incontinence includes non-drug treatment and drug treatment. Non-pharmacological treatment mainly involves self-training of the bladder. This method has a long course of treatment. Patients must have firm perseverance and need to endure physical discomfort for a long time. Drug therapy can quickly relieve symptoms and adjust the patient's body and mind. Therefore, the treatment of urinary incontinence is mainly based on drug therapy.
In terms of anti-incontinence drugs, although traditional anti-acetylcholine drugs have good curative effects and are widely used, serious side effects often make patients repulsive, patients often cannot tolerate, and naturally it is impossible to take long-term medications. Famasia (now Pfizer) successfully pushed Tolterodine onto the market for the characteristics of the market. Tolterodine's clinical trials have shown a therapeutic effect on urinary frequency and urge urinary incontinence, but only moderate and mild side effects, mainly dry mouth, indigestion, dry eyes, headache and constipation. Although tolterodine's adverse reactions were milder, it still caused a large proportion of female patients to withdraw from treatment.
At present, the research and development of anti-incontinence drugs has attracted the attention of the pharmaceutical circles around the world. In recent years, with the continuous in-depth study of the psychiatry, physiology, biochemistry, pharmacology and other aspects of urinary incontinence, the development of related drugs has been continuously achieved. Progress, competition is surging. Tolterodine has been strongly impacted by Vesicare (Solifenacin succinate) of Yamanouchi and Enablex (darifenacin) of Novartis.
The key to the treatment of urinary incontinence drugs is good curative effect, low toxic and side effects, and a wider range of options. Tolterodine is mainly synthesized from cinnamic acid as the main raw material. Research and development experts said that cinnamic acid itself is a spice raw material, without any toxic side effects on the human body. The side effects of tolterodine are mainly due to other compatible ingredients. Through further research on the formulation, it is entirely possible to develop an improved new drug with extremely low side effects, and gram of “social cancer†incontinence for the benefit of patients.
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