Release date: 2018-06-05
Xinhua News Agency, Helsinki, June 2 - Finnish researchers have recently discovered that a highly resistant "superbug", Acinetobacter baumannii, can be attached to plastic medical devices through tiny "finger" structures. This discovery will help medical institutions take steps to stop it from spreading.
Infections associated with hospitals and medical devices have constituted major health care issues worldwide. Studies have shown that such infections are often associated with the ability of pathogens to infect biological and abiotic surfaces.
Anton Zavialov, head of the Joint Biotechnology Laboratory at the University of Turku, Finland, said: "Multi-drug-resistant Acinetobacter baumannii is one of the most difficult pathogens in medical institutions worldwide, and is preferred by the World Health Organization. The list of pathogens for developing new antibiotics tops the list."
The team led by Zavialov used X-ray crystallography to find three finger-like structures on the ACU pili on the surface of Acinetobacter baumannii. These "finger" can be closely attached to the hydrophobic plastics widely used in medical devices and tools, so that the bacteria "settle" to form a biofilm. ACU fimbriae is a hairy protein structure found on the surface of many pathogens.
By binding antibodies to the top of the pili, the researchers completely blocked bacterial adhesion and biofilm formation. The use of hydrophilic materials in place of hydrophobic plastics in medical devices also reduces pathogen spread in a simple and economical manner.
The researchers also found that the highly resistant Pseudomonas aeruginosa also had similar pili and formed a similar biofilm. They predict that the method against Acinetobacter baumannii may be equally applicable to control the spread of Pseudomonas aeruginosa and other similar bacteria. The research report has been published in the new issue of the Proceedings of the National Academy of Sciences.
Source: Xinhuanet
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